Methanol → (S)-methyl 2-amino-4-bromobutanoate hydrobromide

HRID 1160069

Reaktionsgleichung

Reaktionsgleichung von HRID 1160069
O=S(Cl)Cl.Br.[NH2:6][CH:7]([CH2:11][CH2:12][Br:13])[C:8]([OH:10])=[O:9].[CH3:14]O>>[BrH:13].[CH3:14][O:9][C:8](=[O:10])[C@@H:7]([NH2:6])[CH2:11][CH2:12][Br:13]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 138779922-Amino-4-bromobutanoic acid hydrobromide

Produkt 1

HCID 42614181(S)-methyl 2-amino-4-bromobutanoate hydrobromide

Versuchsvorschrift

SOCl2 (7.0 mL) was added slowly to MeOH (100 mL) at −20° C. (bath temp), and stirred for 30 min. 2-Amino-4-bromo-butyric acid hydrobromide (5.0 g, 19 mmol) was then added and the reaction mixture was stirred O/N at rt. Concentration in vacuo gave the title compound as a viscous liquid which become solid on standing: yield 5.2 g (99%).

Aufarbeitung

  1. stirringthe reaction mixture was stirred O/N at rt
  2. concentrationConcentration in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1a3f6388bb0d477e90a6f30b6a9f12ee
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816344B2

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