Thionyl Chloride → 2-(Chloromethyl)-5-(trifluoromethyl)pyridine

HRID 1160221Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1160221
[ClH:1].[F:2][C:3]([F:13])([F:12])[C:4]1[CH:5]=[CH:6][C:7]([CH2:10]O)=[N:8][CH:9]=1.O=S(Cl)[Cl:16]>>[Cl:16][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([F:13])([F:12])[F:2])=[CH:9][N:8]=1.[ClH:1].[Cl:16][CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([F:13])([F:12])[F:2])=[CH:9][N:8]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 68694003(5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt

Produkt 2

HCID 183617202-(Chloromethyl)-5-(trifluoromethyl)pyridineHCID 686914462-(Chloromethyl)-5-(trifluoromethyl)pyridine hydrochloride

Versuchsvorschrift

The mixture of (5-(trifluoromethyl)pyridin-2-yl)methanol HCl salt (293 mg, 1.4 mmol) and SOCl2 (1.5 ml) was stirred for 10 min. After this time, the solution was concentrated under reduced pressure to give the title compound, 2-(chloromethyl)-5-(trifluoromethyl)pyridine HCl salt.

Aufarbeitung

  1. concentrationAfter this time, the solution was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-35205fb3e7a441dd9cf647040934d051
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816357B2

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