Trifluoroacetic acid → (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoic acid hydrochloride

HRID 1160404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1160404
[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C@H:11]([CH2:20][NH:21][CH:22]([CH3:24])[CH3:23])[CH2:12][C:13]([O:15]C(C)(C)C)=[O:14])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].C(O)(C(F)(F)F)=O>C(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C@H:11]([CH2:20][NH:21][CH:22]([CH3:24])[CH3:23])[CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 595162251,1-Dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoate

Produkt 1

HCID 68484641(3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 1,1-dimethylethyl (3S)-3-[(3-chloro-4-cyanophenyl)amino]-4-[(1-methylethyl)amino]butanoate (0.33 g, 0.94 mmol) in CH2Cl2 (2 mL) was treated with TFA (1 mL) for 1.5 h and the reaction was evaporated thoroughly. The residue was treated with 4N HCl in dioxane (4 mL) and then concentrated (this step was done twice) and the crude product was used directly in the next step.

Aufarbeitung

  1. customthe reaction was evaporated thoroughly
  2. additionThe residue was treated with 4N HCl in dioxane (4 mL)
  3. concentrationconcentrated (this step

Quellen und Nachweise

ORD-Eintrag
ord-3a71f1f5eb4d434a888f348f917d3235
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07816395B2

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