Propylene Glycol → 1,1,1,3,3,3-Hexafluoro-2-propanol

HRID 1160441

Reaktionsgleichung

C(O)C(O)C.C1(C)CCC(C(C)C)C(O)C1.C(F)[O:18][CH:19]([C:24]([F:27])([F:26])[F:25])[C:20]([F:23])([F:22])[F:21]>>[CH:19]([OH:18])([C:24]([F:27])([F:26])[F:25])[C:20]([F:23])([F:22])[F:21]

Komponenten

Edukt 3

HCID 1030Propylene Glycol

HCID 1254Menthol

HCID 5206Sevoflurane

Produkt 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanol

Versuchsvorschrift

Table 2 resumes the tests realized with the agents propylene glycol and menthol proposed for the stabilization of sevoflurane against the degradation by alumina and the results for total impurity and for the single impurity HFIP obtained with and without alumina after stress at 60° C. for 22 hours. The total impurity is the sum of the ratio between the area for each impurity and the area of the internal standard (toluene) and HFIP is the ratio between the area of HFIP and the area of toluene obtained in the chromatograms.

Quellen und Nachweise

ORD-Eintrag: ord-177e0a2589fe43c586745e7dff6de1e8
Quelldatensatz: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07816409B2

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