Dimethylformamide → 3-(2-Furyl)-5-[methyl(methylsulfonyl)amino]benzoic acid

Temperatur

100 °C

A mixture of methyl 3-bromo-5-[methyl(methylsulfonyl)amino]benzoate obtained in Reference Example 15 166 mg (0.5.0 mmol), tri-n-butyl(2-furyl)stannane 0.18 mL (0.55 mmol), lithium chloride 42 mg (0.10 mmol), tetrakistriphenylphosphine palladium(0) 29 mg (0.025 mmol) and N,N-dimethylformamide (1.5 mL) was stirred at 100° C. under argon atmosphere for 7 hours. The mixture was diluted with a mixed solvent of ethyl acetate/toluene=1:1 and washed twice with water. After drying of the mixture on magnesium sulfate, the mixture was concentrated and the residual oil was purified by a column chromatography on silica gel (eluted with hexane/ethyl acetate=2:1→1:1). The resulting solid was dissolved in a mixture of 2N aqueous sodium hydroxide solution (2 mL), methanol (2 mL) and tetrahydrofuran (2 mL) and the mixture was stirred at room temperature for 15 hours. The solvent was concentrated and thereto added water and the mixture was washed with a mixed solvent of hexane/ethyl acetate=1:1. The aqueous layer was adjusted by adding 1N hydrochloric acid to pH=3 and the mixture was extracted with ethyl acetate. After drying of the mixture on magnesium sulfate, the solvent was evaporated to give 105 mg (0.355 mmol) of the title compound (yield: 71%).

1. washwashed twice with water
2. customAfter drying of the mixture on magnesium sulfate
3. concentrationthe mixture was concentrated
4. customthe residual oil was purified by a column chromatography on silica gel (eluted with hexane/ethyl acetate=2:1→1:1)
5. dissolutionThe resulting solid was dissolved in a mixture of 2N aqueous sodium hydroxide solution (2 mL), methanol (2 mL) and tetrahydrofuran (2 mL)
6. stirringthe mixture was stirred at room temperature for 15 hours
7. concentrationThe solvent was concentrated
8. washadded water and the mixture was washed with a mixed solvent of hexane/ethyl acetate=1:1
9. additionby adding 1N hydrochloric acid to pH=3
10. extractionthe mixture was extracted with ethyl acetate
11. customAfter drying of the mixture on magnesium sulfate
12. customthe solvent was evaporated

ORD-Eintrag

ord-3feca7309f124ea4be4a2cecc29e5aad

Quelldatensatz

uspto-grants-2010_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07816387B2