7-Methylchroman-2-one → HCID 69655326, Verbindung

HRID 11609Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 11609
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH2:12][C@H:11]([CH3:13])[NH:10][CH2:9][C@H:8]2[CH3:14])=[CH:4][CH:3]=1.[CH3:17][C:18]1[CH:27]=[C:26]2[C:21]([CH2:22][CH2:23][C:24](=[O:28])[O:25]2)=[CH:20][CH:19]=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[C@@H:8]([CH3:14])[CH2:9][N:10]([C:24](=[O:28])[CH2:23][CH2:22][C:21]3[CH:20]=[CH:19][C:18]([CH3:17])=[CH:27][C:26]=3[OH:25])[C@H:11]([CH3:13])[CH2:12]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 2276157-Methylchroman-2-oneHCID 23405839(2R,5S)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine

Produkt 1

HCID 69655326HCID 69655326, VerbindungAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of (2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine (0.25 g, 1.12 mmol) in toluene (10 mL) was added 7-methyl-chroman-2-one (0.25 g, 1.54 mmol) and the resulting solution was heated to reflux for 48 hours. The reaction was cooled, concentrated in vacuo and purified via chromatography on silica gel to give the title compound (0.34 g).

Aufarbeitung

  1. temperaturethe resulting solution was heated
  2. temperatureto reflux for 48 hours
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated in vacuo
  5. custompurified via chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-60ca7772c831497391bbb6d09424b31d
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098212B2

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