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Dimethylformamide → 5-{{3-[2-(t-Butyldimethylsilanyloxy)ethoxy]-2-fluoro-5-methoxyphenyl}-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino]methyl}-2-(3-nitropyridin-2-yl)-2,4-dihydro-[1,2,4]triazol-3-one

HRID 1161565
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1161565
CN(C=O)C.CO[C:8](=[O:47])[N:9]=[C:10](SC)[C:11]([C:25]1[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=[C:27]([O:33][CH2:34][CH2:35][O:36][Si:37]([C:40]([CH3:43])([CH3:42])[CH3:41])([CH3:39])[CH3:38])[C:26]=1[F:44])=[N:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:23]=[C:22]([CH3:24])[O:21][N:20]=2)=[CH:15][CH:14]=1.[N+:48]([C:51]1[C:52]([NH:57][NH2:58])=[N:53][CH:54]=[CH:55][CH:56]=1)([O-:50])=[O:49]>C(N(CC)CC)C>[Si:37]([O:36][CH2:35][CH2:34][O:33][C:27]1[C:26]([F:44])=[C:25]([CH:11]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[N:23]=[C:22]([CH3:24])[O:21][N:20]=3)=[CH:15][CH:14]=2)[C:10]2[NH:9][C:8](=[O:47])[N:57]([C:52]3[C:51]([N+:48]([O-:50])=[O:49])=[CH:56][CH:55]=[CH:54][N:53]=3)[N:58]=2)[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=1)([C:40]([CH3:42])([CH3:43])[CH3:41])([CH3:38])[CH3:39]
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 35789352-Hydrazinyl-3-nitropyridineHCID 72312769(2-{3-[2-(t-Butyldimethylsilanyloxy)ethoxy]-2-fluoro-5-methoxyphenyl}-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene)carbamic acid methyl ester

Produkt 1

HCID 1363892805-{{3-[2-(t-Butyldimethylsilanyloxy)ethoxy]-2-fluoro-5-methoxyphenyl}-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino]methyl}-2-(3-nitropyridin-2-yl)-2,4-dihydro-[1,2,4]triazol-3-one
Ausbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To 3 ml of a DMF solution containing 70 mg of (2-{3-[2-(t-butyldimethylsilanyloxy)ethoxy]-2-fluoro-5-methoxyphenyl}-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene)carbamic acid methyl ester, 19 mg of (3-Nitropyridin-2-yl)hydrazine and 0.017 ml of triethylamine were added. The resulting mixture was stirred at 85° C. for 16 hours and concentrated under reduced pressure. The residue was dissolved in 5 ml of methanol, and 58 mg of sodium cyanotrihydroborate and 0.056 ml of acetic acid were added thereto. The mixture was stirred at room temperature for 15 hours. To this reaction mixture, 40 ml of ethyl acetate and 20 ml of water were added. The organic layer was washed with 20 ml of water and then with 20 ml of saturated brine and dried over anhydrous magnesium sulfate. The desiccating agent was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by NAM silica gel column chromatography (methanol-ethyl acetate) to give the title compound (55 mg).

Aufarbeitung

  1. additionwere added
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residue was dissolved in 5 ml of methanol
  4. addition58 mg of sodium cyanotrihydroborate and 0.056 ml of acetic acid were added
  5. stirringThe mixture was stirred at room temperature for 15 hours
  6. additionTo this reaction mixture, 40 ml of ethyl acetate and 20 ml of water were added
  7. washThe organic layer was washed with 20 ml of water
  8. dry with materialwith 20 ml of saturated brine and dried over anhydrous magnesium sulfate
  9. customThe desiccating agent was removed by filtration
  10. concentrationthe filtrate was concentrated under reduced pressure
  11. customThe residue was purified by NAM silica gel column chromatography (methanol-ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-fe4d92a54ef74fa881fcddefd9fd3b86
Quelldatensatz
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07816522B2

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