Sodium hydride → HCID 58626094, Verbindung

HRID 1161696

Reaktionsgleichung

Reaktionsgleichung von HRID 1161696
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([Cl:12])[CH:5]=1)=[O:3].[H-].[Na+].C([O:17][C:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1)C>CN(C=O)C>[Cl:12][C:6]1[CH:5]=[C:4]([C:2](=[O:3])[CH2:1][C:18]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)=[O:17])[CH:9]=[CH:8][C:7]=1[O:10][CH3:11]

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 69188Ethyl NicotinateHCID 5208573'-Chloro-4'-methoxyacetophenone

Produkt 1

HCID 58626094HCID 58626094, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

To a solution of 3-chloro-4-methoxy acetophenone (3.0 g, 16.30 mmol) in DMF (15 mL) was added 60% NaH [0.717 g (0.430 g, 17.93 mmol)] at 0° C. under a nitrogen atmosphere. The mixture was stirred for 30 min and a solution of nicotinic acid ethyl ester (2.95 g, 19.56 mmol) in DMF (10 mL) was added slowly to it. The mixture was stirred at temperature in the range of 20-40° C. for 12 hour. It was then poured into ice-cold water (100 mL) and stirred for 15 minutes. The solid was filtered and dried to give the desired compound.

Aufarbeitung

  1. stirringThe mixture was stirred at temperature in the range of 20-40° C. for 12 hour
  2. stirringstirred for 15 minutes
  3. filtrationThe solid was filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1fe0fc5df7554c94bef352c71a8b9a7d
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820654B2

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