Hydrochloric Acid → 4-(5-Chloro-2-hydroxy-phenyl)-4-oxo-butyric Acid Ethyl Ester

HRID 11621Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 11621
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:15])=[C:6]([C:8](=[O:14])[CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:7]=1.Cl.[CH2:17](O)[CH3:18]>>[CH2:17]([O:12][C:11](=[O:13])[CH2:10][CH2:9][C:8]([C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[OH:15])=[O:14])[CH3:18]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 41452424-(5-Chloro-2-hydroxyphenyl)-4-oxobutanoic acid

Produkt 1

HCID 684473744-(5-Chloro-2-hydroxy-phenyl)-4-oxo-butyric Acid Ethyl Ester

Versuchsvorschrift

A solution of 4-(5-chloro-2-hydroxy-phenyl)-4-oxo-butyric acid (0.25 g, 1.09 mmol) in ethanol (10 mL) saturated with hydrogen chloride (g) was stirred at ambient temperature for 12 hours. The reaction was concentrated in vacuo, dissolved in diethyl ether and washed with saturated aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo to give the title compound (0.259 g).

Aufarbeitung

  1. concentrationThe reaction was concentrated in vacuo
  2. dissolutiondissolved in diethyl ether
  3. washwashed with saturated aqueous sodium bicarbonate
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-44dafea2b06842acb7dacd01a2391aa6
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098212B2

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