Thionyl Chloride → 4-Pyridinecarboxylic acid, 3-(chlorocarbonyl)-, methyl ester

HRID 1162561Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1162561
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][C:6]=1[C:11]([OH:13])=O)=[O:4].S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:4])[C:5]1[CH:10]=[CH:9][N:8]=[CH:7][C:6]=1[C:11]([Cl:16])=[O:13]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 3275254-(Methoxycarbonyl)pyridine-3-carboxylic acid

Produkt 1

HCID 140051554-Pyridinecarboxylic acid, 3-(chlorocarbonyl)-, methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

3-Chlorocarbonyl-isonicotinic acid methyl ester was prepared by refluxing a mixture of pyridine-3,4-dicarboxylic acid 4-methyl ester (100 mg) and thionyl chloride (75 μl) in chloroform (5 ml) for 3 h. After cooling to room temperature, volatiles were evaporated, and the residue was dried under high vacuum to give the product (100 mg).

Aufarbeitung

  1. temperatureby refluxing
  2. customvolatiles were evaporated
  3. customthe residue was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-09d26c715f4b4a9eaf26d95e423992c4
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820704B2

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