(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)-acetic acid tert-butyl ester → [3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetic acid

HRID 1162736

Reaktionsgleichung

Reaktionsgleichung von HRID 1162736
C([O:5][C:6](=[O:21])[CH2:7][N:8]1[C:16]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[C:10]([C:17]([F:20])([F:19])[F:18])=[N:9]1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[F:20][C:17]([F:18])([F:19])[C:10]1[C:11]2[CH2:12][CH2:13][CH2:14][CH2:15][C:16]=2[N:8]([CH2:7][C:6]([OH:21])=[O:5])[N:9]=1

Komponenten

4

Edukt 1

HCID 68647733(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)-acetic acid tert-butyl ester

Produkt 1

HCID 788039[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)-acetic acid tert-butyl ester was dissolved in a solution of DCM (30 mL) and TFA (30 mL), and the resulting mixture stirred at RT for 30 min, before concentration in vacuo to afford the title compound (4.50 g). This was used directly in the next step without any further purification.

Quellen und Nachweise

ORD-Eintrag
ord-348c038903f14f3dbdef867e442da7e8
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820707B2

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