Hydrochloric Acid → 2-Ethoxy-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone

HRID 1163471

Reaktionsgleichung

Reaktionsgleichung von HRID 1163471
[OH-].[K+].Br[CH2:4][C:5]([C:7]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:10]([OH:17])=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:8]=1)=[O:6].Cl.[CH2:23]([OH:25])[CH3:24]>>[CH2:23]([O:25][CH2:4][C:5]([C:7]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:10]([OH:17])=[C:9]([C:18]([CH3:21])([CH3:20])[CH3:19])[CH:8]=1)=[O:6])[CH3:24]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 6161612-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one

Produkt 1

HCID 577472312-Ethoxy-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone

Versuchsvorschrift

Under inert atmosphere 8.4 g (150 mmol) of potassium hydroxide is dissolved in 150 ml of ethanol. After adding 10.0 g (31 mmol) of 2-bromo-1-(4-hydroxy-3,5-di-tert-butylphenyl)-ethanone in portions at room temperature stirring is continued for 16 hours. Then the reaction mixture is acidified with 10% HCl and extracted with ethylacetate. The collected organic phases are washed with water and brine, dried and evaporated. Crystallization of the crude product from hexane gives 3.8 g of compound 113, m.p. 73-75° C.

Aufarbeitung

  1. extractionextracted with ethylacetate
  2. washThe collected organic phases are washed with water and brine
  3. customdried
  4. customevaporated
  5. customCrystallization of the crude product from hexane

Quellen und Nachweise

ORD-Eintrag
ord-fd8cb560517341caa04989e8aec8127b
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07820865B2

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