Thionyl Chloride → 2-Chlorophenyl 2-methoxy-3-chloromethylphenyl thioether

HRID 1164080Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1164080
[CH3:1][O:2][C:3]1[C:10]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.S(Cl)([Cl:21])=O>N1C=CC=CC=1.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]([CH2:5][Cl:21])=[CH:7][CH:8]=[CH:9][C:10]=1[S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18]

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 53999561HCID 53999561, Verbindung

Produkt 1

HCID 205134642-Chlorophenyl 2-methoxy-3-chloromethylphenyl thioether

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

A mixture of 2-methoxy-3-(2-chlorophenylthio)benzyl alcohol (9 g), thionyl chloride (4.6 ml) and pyridine (3 drops) in dried benzene (60 ml) was refluxed under heating for 30 minutes. The reaction mixture was cooled to the ambient temperature and evaporated under reduced pressure. The residue was dissolved in diethyl ether, and the solution was washed with water, saturated aqueous sodium bicarbonate and water in turn, dried over magnesium sulfate and then evaporated under reduced pressure to give oily 2-chlorophenyl 2-methoxy-3-chloromethylphenyl thioether (9.2 g).

Aufarbeitung

  1. temperaturewas refluxed
  2. temperatureunder heating for 30 minutes
  3. customevaporated under reduced pressure
  4. dissolutionThe residue was dissolved in diethyl ether
  5. washthe solution was washed with water, saturated aqueous sodium bicarbonate and water in turn
  6. dry with materialdried over magnesium sulfate
  7. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ee3ee6d3e94e4c04bc8dd8a29e34a833
Quelldatensatz
uspto-grants-1983_01
Patentnummer
US04367238

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