4-Nitro-1-indanyl acetate → 4-Amino-1-indanyl acetate

HRID 1164204

Reaktionsgleichung

Reaktionsgleichung von HRID 1164204
[C:1]([O:4][CH:5]1[C:13]2[C:8](=[C:9]([N+:14]([O-])=O)[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pt]=O>[C:1]([O:4][CH:5]1[C:13]2[C:8](=[C:9]([NH2:14])[CH:10]=[CH:11][CH:12]=2)[CH2:7][CH2:6]1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 131024574-Nitro-1-indanyl acetateHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 131024584-Amino-1-indanyl acetateAusbeute 97,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 10.0 g (0.045 mole) of 4-nitro-1-indanyl acetate in 200 mL of ethanol was mixed with 0.1 g of platinum oxide in 20 mL of ethanol, and the mixture was contacted with hydrogen in a Parr hydrogenator. Upon complete uptake of hydrogen, the reaction mixture was allowed to stand for 16 hours. The platinum oxide was removed by filtration through diatomaceous earth, and the filter cake was washed with ethanol. The ethanol washings were combined with the filtrate, and the whole was concentrated under reduced pressure to give 8.4 g of 4-amino-1-indanyl acetate as an oil.

Aufarbeitung

  1. customThe platinum oxide was removed by filtration through diatomaceous earth
  2. washthe filter cake was washed with ethanol
  3. concentrationthe whole was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8995f2dd71d345569966a4f8e813ca65
Quelldatensatz
uspto-grants-1983_01
Patentnummer
US04368205

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