Methanol → Methyl 3-(2-hydroxyphenyl)prop-2-enoate

HRID 1164998

Reaktionsgleichung

Reaktionsgleichung von HRID 1164998
[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[CH3:13]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH3:13])=[O:7]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 119683-(2-Hydroxyphenyl)-2-propenoic acid

Produkt 1

HCID 89400Methyl 3-(2-hydroxyphenyl)prop-2-enoateAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidKatalysator

Versuchsvorschrift

A solution of 200 g (1.218 mole) of 2-hydroxycinnamic acid in 2L of anhydrous methanol was treated with 10 drops of concentrated sulfuric acid. This solution was refluxed for 72 hr., using a Soxhlet extractor charged with 200 g of 3A molecular sieves. The methanolic solution was then concentrated under reduced pressure and cooled to afford 200 g (92%) of white crystals, which were used directly in the next step without additional purification.

Aufarbeitung

  1. temperatureThis solution was refluxed for 72 hr
  2. concentrationThe methanolic solution was then concentrated under reduced pressure
  3. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-be57951fd8e942fcb9f559f8ba454413
Quelldatensatz
uspto-grants-1990_03
Patentnummer
US04906661

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