3-Hydroxyphenacyl bromide → N-[4-[2-[[6-[[2-(3-Hydroxyphenyl)-2-oxoethyl](phenylmethyl)amino]hexyl]oxy]ethyl]phenyl]acetamide

Beteiligte Stoffe

Reaktionsschritte

A solution of N-[4-[2-[[6-[(phenylmethyl)amino]hexyl]oxy]ethyl]phenyl]acetamide (1 g), 2-bromo-1-(3-hydroxyphenyl)ethanone (0.61 g) and DEA (0.8 g) in dichloromethane (20 ml) was stirred under nitrogen for 18 h, diluted with water (20 ml), and extracted with dichloromethane (25 ml). The organic layer was washed with 8% sodium bicarbonate solution (20 ml), dried and evaporated in vacuo to give the title compound as a yellow oil (0.71 g).

Herkunft & Nachweise