Methoxyacetyl chloride → 3,5-Bis(methoxyacetylamino)-4-chlorobenzonitrile

HRID 1165880Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1165880
[Cl:1][C:2]1[C:9]([NH2:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[NH2:11].[CH3:12][O:13][CH2:14][C:15](Cl)=[O:16]>N1C=CC=CC=1>[CH3:12][O:13][CH2:14][C:15]([NH:11][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([NH:10][C:15](=[O:16])[CH2:14][O:13][CH3:12])[C:2]=1[Cl:1])[C:6]#[N:7])=[O:16]

Komponenten

4

Edukt 2

HCID 96623Methoxyacetyl chlorideHCID 124029953,5-Diamino-4-chlorobenzonitrile

Produkt 1

HCID 146992833,5-Bis(methoxyacetylamino)-4-chlorobenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 4-chloro-3,5-diaminobenzonitrile (3.34 g) in pyridine (60 ml) is added dropwise methoxyacetyl chloride (4.0 ml) at room temperature. The mixture is stirred at room temperature for 2 hours, and thereafter, pyridine is distilled off under reduced pressure. To the residue is added water, and the resulting solid substance is separated by filtration and washed with water. The resulting crude crystals are recrystallized from ethanol to give the title compound (5.1 g) having the following physical properties.

Aufarbeitung

  1. distillationpyridine is distilled off under reduced pressure
  2. additionTo the residue is added water
  3. customthe resulting solid substance is separated by filtration
  4. washwashed with water
  5. customThe resulting crude crystals are recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-012e51196b8f4431b52d32b3bb8cf243
Quelldatensatz
uspto-grants-1990_03
Patentnummer
US04912135

Notizen zur Reaktion

Wird geladen…