1-Benzylpiperazine → 2-(4-Chlorophenyl)-4-(4-benzylpiperazino)-6,7,8-trimethoxyquinazoline

HRID 1166151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1166151
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](Cl)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[CH2:25]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([N:35]3[CH2:36][CH2:37][N:32]([CH2:25][C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:33][CH2:34]3)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 759941-BenzylpiperazineHCID 117834712-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

Produkt 1

HCID 111239992-(4-Chlorophenyl)-4-(4-benzylpiperazino)-6,7,8-trimethoxyquinazoline

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

A mixture of 2.0 g of 2-(4-chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline and 5.0 g of N-benzylpiperazine was heated at 150° C. for 1 h. After cooling, 20 ml of ice water were added and the mixture was extracted with ethyl acetate. The organic phase was dried over sodium sulfate and concentrated. The oily crude product thus obtained was recrystallized from isopropanol. Yield: 1 g. M.p.: 150° C.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6747592a7e76453cb68696400a8b36fa
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06613772B1

Notizen zur Reaktion

Wird geladen…