HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → (S)-3-Cyclohexylbutyroyl Chloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Oxalyl chloride | HCID 65578 | — |
| Edukt | (3S)-3-phenylbutanoic acid | HCID 852991 | — |
| Katalysator | Rhodium | HCID 23948 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | (S)-3-Cyclohexylbutyroyl Chloride | HCID 12085190 | — |
Reaktionsschritte
(S)-3-phenylbutyric acid was hydrogenated using Rh/C in MeOH at 60 psi and 60° C. for 3.2 hours. The reduced product was then converted to the title acid chloride by treating with 1 eq of oxalyl chloride, and a catalytic amount of DMF, in toluene for 90 minutes, followed by evaporation of the volatile materials.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06613880B2 |
| Quelldatensatz | uspto-grants-2003_09 |
| ORD ID | ord-e425d4f156254adc9d08a4f60024b1b6 |
| Quellennotiz | uspto-grants-2003_09 |