Triethylamine → Methyl 2-methyl-2-phenyl-5-{4-[(biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate

HRID 1167107

Reaktionsgleichung

[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:11]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:9])[CH2:3][CH2:2]1.Br[CH2:23][CH2:24][CH2:25][C:26]([CH3:38])([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:27][C:28]([O:30][CH3:31])=[O:29].C(N(CC)CC)C>CN(C)C=O>[CH3:38][C:26]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)([CH2:25][CH2:24][CH2:23][N:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:11]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:9])[CH2:3][CH2:2]1)[CH2:27][C:28]([O:30][CH3:31])=[O:29]

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

A solution of 0.634 g (0.002 mol) of biphenyl-2-carboxylic acid-piperidin-4-ylamide, 0.5 g (1.75 mmol) of methyl 5-bromo-2-methyl-2-phenyl-pentanecarboxylate and 1 ml (0.007 mol) of triethylamine are dissolved in 3 ml dimethylformamide. The mixture is stirred for 14 hours at 80° C. Then the reaction mixture is poured onto water and extracted with ethyl acetate. The organic phase is dried over sodium sulphate. After column chromatography on silica gel (eluant: dichloromethane/methanol=10:1) colourless crystals remain.

Aufarbeitung

additionThen the reaction mixture is poured onto water
extractionextracted with ethyl acetate
dry with materialThe organic phase is dried over sodium sulphate

Quellen und Nachweise

ORD-Eintrag: ord-be0aaedc435e4e1c9fd25e02e5d8de5a
Quelldatensatz: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06617325B1

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