Methyl 2-methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate → 2-Methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylic acid

HRID 1167108

Reaktionsgleichung

Reaktionsgleichung von HRID 1167108
[CH3:1][C:2]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:13][CH2:12]1)[CH2:3][C:4]([O:6]C)=[O:5]>Cl>[CH3:1][C:2]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:27]=[CH:28][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:30][CH:31]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:15][CH2:16]1)[CH2:3][C:4]([OH:6])=[O:5]

Komponenten

3

Edukt 1

HCID 22995529Methyl 2-methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate

Produkt 1

HCID 229956572-Methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A suspension of 1.5 g (0.0027 mol) of methyl 2-methyl-2-phenyl-5-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate in 60 ml of 6N hydrochloric acid is refluxed for 25 hours. After cooling the precipitate is filtered off and washed with water and ethyl acetate.

Aufarbeitung

  1. temperatureis refluxed for 25 hours
  2. temperatureAfter cooling the precipitate
  3. filtrationis filtered off
  4. washwashed with water and ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-de572782bbc54cb987698d8e06304563
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06617325B1

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