Hydrochloric Acid → HCID 12282158, Verbindung

Reaktionsgleichung

Cl.[Cl:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[CH2:11]([OH:13])[CH3:12]>>[ClH:2].[Cl:2][C:3]1[CH:10]=[CH:9][C:6]([C:7](=[NH:8])[O:13][CH2:11][CH3:12])=[CH:5][CH:4]=1

Komponenten

Edukt 3

HCID 313Hydrochloric Acid2×

HCID 702Ethanol

HCID 121634-Chlorobenzonitrile

Produkt 1

HCID 12282158HCID 12282158, VerbindungAusbeute 83 %

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

Hydrogen chloride gas was passed through a solution of 4-chloro-benzonitrile (1.0 g, 7.3 mmol) in anhydrous ethanol (100 mL) cooled to 0° C. After 3 h, hydrogen chloride gas was stopped and the reaction mixture was stirred at room temperature for 16 h. The solvent was removed and the residue was triturated in diethyl ether to afford ethyl 4-chloro-benzimidate hydrochloride (1.12 g, 83%). It was used without further purification.