HCID 497421, Verbindung → HCID 497413, Verbindung

HRID 1167472

Reaktionsgleichung

Reaktionsgleichung von HRID 1167472
O[CH:2]1[CH2:5][N:4]([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:16][C@H:15]([CH2:17][O:18][C:19]4[CH:23]=[CH:22][O:21][N:20]=4)[O:14][C:13]3=[O:24])=[CH:8][C:7]=2[F:25])[CH2:3]1.FC1C=C(N2C[C@H](CO)OC2=O)C=C[C:32]=1[N:33]1C=C(C)N=C1>>[F:25][C:7]1[CH:8]=[C:9]([N:12]2[CH2:16][C@H:15]([CH2:17][O:18][C:19]3[CH:23]=[CH:22][O:21][N:20]=3)[O:14][C:13]2=[O:24])[CH:10]=[CH:11][C:6]=1[N:4]1[CH:3]=[C:2]([CH3:5])[N:33]=[CH:32]1

Komponenten

3

Edukt 2

HCID 497421HCID 497421, VerbindungHCID 21356561(5R)-3-(3-Fluoro-4-(4-methylimidazol-1-yl)phenyl)-5-hydroxymethyloxazolidin-2-one

Produkt 1

HCID 497413HCID 497413, Verbindung

Versuchsvorschrift

Using essentially the same procedure as for the intermediate of Example 65, but starting with 3-(3-fluoro-4-(4-methyl-imidazol-1-yl)phenyl)-5(R)-hydroxymethyloxazolidin-2-one (see Example 141; 81 mg, 0.29 mmol), and purifying by chromatography on a 5 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 0 to 2.5% MeOH in dichloromethane, gave the title compound (80 mg). MS (ESP): 359 (MH+) for C17H15FN4O4.

Aufarbeitung

  1. custompurifying by chromatography on a 5 g silica Mega Bond Elut® column
  2. washeluting with a gradient
  3. temperatureincreasing in polarity from 0 to 2.5% MeOH in dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-676689885d374ceda4ff464daee93722
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06617339B1

Verknüpfte Notizen

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