Acetyl chloride → HCID 12970146, Verbindung

HRID 1167891Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1167891
[N+:1]([CH2:4][C:5]1([CH2:11][CH2:12][NH2:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)([O-:3])=[O:2].[C:14](Cl)(=[O:16])[CH3:15].C(N(CC)CC)C>O1CCCC1>[N+:1]([CH2:4][C:5]1([CH2:11][CH2:12][NH:13][C:14](=[O:16])[CH3:15])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 12970145HCID 12970145, Verbindung2×

Produkt 1

HCID 12970146HCID 12970146, VerbindungAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The amine hydrochloride salt (compound 4, 0.50 g, 2.25 mmol) was reacted with acetyl chloride (0.20 g, 2.55 mmol) and triethylamine (0.45 g, 4.45 mmol) in tetrahydrofuran following the procedure described in Example 1, Step 4. Purification by chromatography on silica eluting with ethyl acetate gave the required product as a crystalline solid (0.35 g, 69%); mp 68-70° C.

Aufarbeitung

  1. customPurification by chromatography on silica eluting with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-f78687b871ff4feaaa20482a61d4d847
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06620829B2

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