(17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) hydrogen sulfate → Glycine

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FIG. 19 contains two graphs of data indicating pregnenolone sulfate (PS) differentially modulate NR1011/2A and NR1111/2A splice variants at pH 8.5. Data points are averaged normalized peak NMDA-induced current responses obtained from oocytes injected with (A) NR1011/2A or (B) NR1111/2A mRNAs. Concentration-response data for NMDA (circles) and for NMDA+100 μM PS (squares) were obtained in the presence of 10 μM glycine. Fitted parameters are (A) (control ◯, n=11), EC50=94 μM, Emax=1.30, nH=1.62; (+PS, open squares, n=10), EC50=58 μM, Emax=1.62, nH=1.44; (B) (control, closed circles, n=10), EC50=110 μM, Emax=1.35, nH=1.93; (+PS, closed squares, n=23), EC50=94 μM, Emax=1.98, nH=1.82. The data were normalized relative to the current induced by co-application of 200 μM NMDA and 10 μM glycine to the same oocyte. Error bars represent S.E.M.

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