Trifluoroacetic acid → 2-amino-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

HRID 11686

Reaktionsgleichung

Reaktionsgleichung von HRID 11686
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][C@H:15]([CH3:17])[N:14]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH2:13][C@H:12]1[CH3:26])=[O:10])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][C@H:15]([CH3:17])[N:14]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=2)[CH2:13][C@H:12]1[CH3:26])=[O:10]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69655545{2-[4-(4-Fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethyl}-carbamic Acid tert-butyl Ester

Produkt 1

HCID 696557642-amino-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanoneAusbeute 112,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of {2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester (1.45 g, 3.28 mmol) in dichloromethane (38 mL) was added trifluoroacetic acid (20 mL). The reaction was stirred at ambient temperature for two hours. The reaction was diluted with dichloromethane and washed with 1N sodium hydroxide. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated to the give the title compound (1.03 g).

Aufarbeitung

  1. washwashed with 1N sodium hydroxide
  2. customThe organic layer was separated
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated to the

Quellen und Nachweise

ORD-Eintrag
ord-a298c342cfc74e5f87a5ae2028897c0b
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098212B2

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