Ammonia → 5-(Benzyloxy)pyridin-3-amine

Temperatur

180 °C

A thick-walled glass pressure tube was charged with copper(II) sulfate pentahydrate (1.96 g, 7.85 mmol), 5-bromo-3-(phenylmethoxy)pyridine (4.00 g, 15.15 mmol) and concentrated aqueous ammonia (29.7%, 14.8 M, 37 mL). The tube was sealed and the dark blue suspension was stirred and heated at ˜180° C. (oil bath temperature) for 24 h. The mixture was allowed to cool to ambient temperature. After further cooling in an ice-water bath, the mixture was concentrated on a rotary evaporator to a small volume (˜20 mL) of a dark-blue solution. The solution was diluted with water (40 mL) and saturated K2CO3 solution (40 mL) and extracted with CHCl3 (4×40 mL). The combined, turbid-brown CHCl3 extracts were washed with saturated NaCl solution (2×100 ml), dried (Na2SO4), filtered and concentrated (rotary evaporator). The resulting dark-brown oil, was briefly dried on the vacuum pump to give a dark-brown solid (2.06 g). The product was purified by column chromatography on silica gel (100 g) eluting with CHCl3—MeOH (3:1,v/v). Selected fractions, based on TLC (Rf 0.65) analysis, were combined and concentrated to give a 1.64 g(54.1%) of a tan-brown solid.

1. customThe tube was sealed
2. temperatureto cool to ambient temperature
3. temperatureAfter further cooling in an ice-water bath
4. concentrationthe mixture was concentrated on a rotary evaporator to a small volume (˜20 mL) of a dark-blue solution
5. additionThe solution was diluted with water (40 mL) and saturated K2CO3 solution (40 mL)
6. extractionextracted with CHCl3 (4×40 mL)
7. washturbid-brown CHCl3 extracts were washed with saturated NaCl solution (2×100 ml)
8. dry with materialdried (Na2SO4)
9. filtrationfiltered
10. concentrationconcentrated
11. custom(rotary evaporator)
12. customThe resulting dark-brown oil, was briefly dried on the vacuum pump

ORD-Eintrag

ord-19c7fca597cb45329d889d6062cb0dd7

Quelldatensatz

uspto-grants-2003_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06627648B1