Hydrochloric Acid → 4-amino-1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]piperidine dihydrochloride

HRID 1169407Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1169407
[CH3:1][N:2]([CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][CH2:12]1)[CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[ClH:25]>C(O)C>[ClH:25].[ClH:25].[NH2:17][CH:14]1[CH2:13][CH2:12][N:11]([CH2:10][CH2:9][N:2]([CH3:1])[CH:3]2[CH2:8][CH2:7][O:6][CH2:5][CH2:4]2)[CH2:16][CH2:15]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 70023872tert-butyl 1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]-4-piperidinylcarbamate

Produkt 1

HCID 229899814-amino-1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]piperidine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Into a solution of tert-butyl 1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]-4-piperidinylcarbamate (2.72 g) in ethanol (30 ml) was added concentrated hydrochloric acid (10 ml), and the resulting mixture was stirred for 7 hours. After the reaction mixture was concentrated under reduced pressure, ethanol and methanol are added to the residue, and the resulting mixture was concentrated further. The precipitate was collected by filtration and was washed with ethanol and methanol to obtain 4-amino-1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]piperidine dihydrochloride (1.65 g) as a light yellow powder.

Aufarbeitung

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure, ethanol and methanol
  2. additionare added to the residue
  3. concentrationthe resulting mixture was concentrated further
  4. filtrationThe precipitate was collected by filtration
  5. washwas washed with ethanol and methanol

Quellen und Nachweise

ORD-Eintrag
ord-5a542f1c05824a9bb4f1fd32cd762dce
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06627651B1

Notizen zur Reaktion

Wird geladen…