Methyl iodide → HCID 22990064, Verbindung

HRID 1169435Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1169435
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:28]=[CH:29][CH:30]=1)[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:17][CH:16]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[I:32].[C:33](OCC)(=O)C>CN(C=O)C>[I-:32].[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:28]=[CH:29][CH:30]=1)[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N+:22]2([CH3:33])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]2)=[CH:17][CH:16]=1)=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 29671333-(Phenylmethoxy)-N-[4-(1-piperidinylmethyl)phenyl]benzamide

Produkt 1

HCID 22990064HCID 22990064, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To 3-benzyloxy -4′-(piperidinomethyl)benzanilide (560 mg) dissolved in DMF (3 ml) was added methyl iodide (261 μl), and the resulting mixture was stirred at room temperature for 14 hours. Ethyl acetate (100 ml) was added to this reaction mixture, and the resulting precipitate was collected by filtration to obtain 1-[4-(3-benzyloxybenzoylamino)benzyl]-1-methylpiperidinium iodide (compound 87) (724 mg) as colorless crystals.

Aufarbeitung

  1. filtrationthe resulting precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-cebaaf440f524928b6888f9b4a0003b1
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06627651B1

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