1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 59550583, Verbindung

HRID 1169570

Reaktionsgleichung

Reaktionsgleichung von HRID 1169570
[CH2:1]([O:3][C:4]([CH:6]1[CH2:12][CH2:11][N:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[C:9]2[CH:23]=[CH:24][CH:25]=[CH:26][C:8]=2[C:7]1=[O:27])=[O:5])[CH3:2].Br[CH2:29][CH2:30][N:31]1[C:35](=[O:36])[C:34]2=[CH:37][CH:38]=[CH:39][CH:40]=[C:33]2[C:32]1=[O:41]>>[CH2:1]([O:3][C:4]([C:6]1([CH2:29][CH2:30][N:31]2[C:32](=[O:41])[C:33]3[C:34](=[CH:37][CH:38]=[CH:39][CH:40]=3)[C:35]2=[O:36])[CH2:12][CH2:11][N:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)(=[O:14])=[O:15])[C:9]2[CH:23]=[CH:24][CH:25]=[CH:26][C:8]=2[C:7]1=[O:27])=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 12435934Ethyl 5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylate

Produkt 1

HCID 59550583HCID 59550583, Verbindung

Versuchsvorschrift

The title compound was prepared from 5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester and N-(2-bromoethyl)phthalimide as described in Example 1. 1H NMR (CDCl3) δ 7.85(m, 4H), 7.75(m, 4H), 7.55-7.45(m, 2H), 7.4-7.35(m, 1H), 7.25-7.2(m, 1H), 4.2-4.0(m, 6H), 3.9-3.85(m, 1H), 3.65-3.55(m, 3H), 3.4(br s, 1H), 2.4(s, 3H), 2.4-2.35(m, 1H), 1.35-1.15(m, 3H). MS (ES) m/z 583(MNa)+

Quellen und Nachweise

ORD-Eintrag
ord-6b8912f2e098486ea6bb3e64fe88e3ab
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825110B2

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