2-Fluorophenyl isocyanate → HCID 42605083, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]=[C:10]([O:17][S:18]([C:21]([F:24])([F:23])[F:22])(=[O:20])=[O:19])[C:9]=2[C:25]#[N:26])=[CH:4][CH:3]=1.[F:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[N:34]=[C:35]=[O:36]>>[C:25]([C:9]1[C:10]([O:17][S:18]([C:21]([F:23])([F:24])[F:22])(=[O:20])=[O:19])=[N:11][C:12]([CH:14]2[CH2:15][CH2:16]2)=[CH:13][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:35]([NH:34][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[F:27])=[O:36])=[CH:7][CH:6]=1)#[N:26]Komponenten
3
Versuchsvorschrift
In analogy to GP 4, reaction of 200 mg trifluoromethanesulphonic acid 4-(4-amino-phenyl)-3-cyano-6-cyclopropyl-pyridin-2-yl ester (0.522 mmol) and 71 μl 1-fluoro-2-isocyanato-benzene yielded 179 mg product (0.343 mmol, 66% yield).
Quellen und Nachweise
- ORD-Eintrag
- ord-9513aa9f12114713be87be169911f7f0
- Quelldatensatz
- uspto-grants-2010_11