N-(2-Aminoethyl)piperidine → (2-Chloro-5-(2-thienyl)pyrimidine-4-yl)-(2-piperidin-1-yl-ethyl)-amine
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[N:10]1([CH2:16][CH2:17][NH2:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.CC1(C)C(C)(C)OB([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)O1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:18][CH2:17][CH2:16][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[C:5]([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)=[CH:4][N:3]=1Komponenten
4
Versuchsvorschrift
Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodopyrimidine, 2-piperidin-1-yl-ethylamine and 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane.