HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Formamide → Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Formamide | HCID 713 | — |
| Edukt | 1-Piperazinecarboxylic acid, 4-[2-(ethoxycarbonyl)-5-benzofuranyl]-, 1,1-dimethylethyl ester | HCID 11176275 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Produkt | Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate | HCID 11244883 | — |
Reaktionsschritte
A solution of 3 g of ethyl 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate in 100 ml of N-methylpyrrolidone is stirred for 5 hours with 1 g of formamide and 3 g of sodium alkoxide. After customary working up, 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide, m.p. 198°-200°, is obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05723614 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-7d431b55cb724be5bee26d49a4283c0c |
| Quellennotiz | uspto-grants-1998_03 |