1-(5-Fluoro-2-methoxyphenyl)methanamine → HCID 68433764, Verbindung
Reaktionsgleichung
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][C:13](Cl)=[N:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:20][C:21]1[CH:22]=[CH:23][C:24]([O:29][CH3:30])=[C:25]([CH:28]=1)[CH2:26][NH2:27]>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][C:13]([NH:27][CH2:26][C:25]1[CH:28]=[C:21]([F:20])[CH:22]=[CH:23][C:24]=1[O:29][CH3:30])=[N:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
5-Benzyloxy-2-chloroquinoline (155 mg, 0.56 mmol) and 5-Fluoro-2-methoxybenzylamine (CAS 1978-39-8) (268 mg, 1.68 mmol) were stirred in a sealed tube at 90° C. for 16 hours. The reaction mixture was purified by flash chromatography on silica gel (heptane/ethyl acetate 100:0->50:50 gradient). (5-Benzyloxy-quinolin-2-yl)-(5-fluoro-2-methoxy-benzyl)-amine was obtained as a colorless oil (40 mg, 18%),
Aufarbeitung
- customThe reaction mixture was purified by flash chromatography on silica gel (heptane/ethyl acetate 100:0->50:50 gradient)