Pyrrolidine → (3-Bromobenzoyl)pyrrolidine
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([C:5]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:6])[CH:8]=[CH:9][CH:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 3-bromo-benzoyl chloride (2.7 g, 12 mmol) in DCM (40 mL) was chilled to zero degrees and treated with pyrrolidine (3 mL, 36.8 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (3.1 g, 100%).
Aufarbeitung
- customReaction
- customto come to room temperature
- additionMixture was then poured onto water
- washwashed once
- washOrganic phase then washed with brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated to amber oil (3.1 g, 100%)
Quellen und Nachweise
- ORD-Eintrag
- ord-31a4e978fa7643549e58ee5d1c9685e2
- Quelldatensatz
- uspto-grants-2010_11
- Patentnummer
- US07825246B2
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