1,4-Dioxane hydrochloride → 1-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

HRID 1172447Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1172447
[Cl:1][C:2]1[C:3]([F:23])=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([N:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)=[O:6].Cl.O1CCOCC1>CO>[ClH:1].[Cl:1][C:2]1[C:3]([F:23])=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)=[O:6]

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57562582Tert-butyl 4-(3-chloro-2-fluorobenzoyl)piperazine-1-carboxylate

Produkt 1

HCID 686779601-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a mixture of 35.1 g of tert-butyl 4-(3-chloro-2-fluorobenzoyl)piperazine-1-carboxylate and 50 ml of methanol was added a hydrochloric acid-1,4-dioxane solution (4 M, 100 ml) followed by stirring at room temperature for 2.5 hours. The reaction mixture was concentrated in vacuo and the residue was suspended in diethyl ether, filtered and collected to give the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationfiltered
  3. customcollected

Quellen und Nachweise

ORD-Eintrag
ord-53a6ea84fea047dd91abeb6846450255
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834018B2

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