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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1172617Erstellt: 27. Oktober 2026

Benzene, 1-fluoro-2-methyl-4-nitro- → 1-(2-Hydroxyethyl)-4-(2-methyl-4-nitrophenyl)piperazine

https://huagongshe.com/reaction/1172617

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktBenzene, 1-fluoro-2-methyl-4-nitro-HCID 68001—
EduktDiisopropylethylamineHCID 81531—
Edukt1-(2-Ethoxyethyl)piperazineHCID 2734643—
LösungsmittelDimethyl SulfoxideHCID 679—
Produkt1-(2-Hydroxyethyl)-4-(2-methyl-4-nitrophenyl)piperazineHCID 61151226—

Reaktionsschritte

In the same manner as in Production Example 5-1, but using 4-(2-ethoxyethyl)piperazine in place of N-ethylpiperazine used in Production Example 5-1, using 5-nitro-2-fluorotoluene in place of 2-fluoro-5-nitrobenzyl alcohol, using N,N-diisopropylethylamine in place of potassium carbonate, and using dimethylsulfoxide in place of N-methylpyrrolidone, the entitled compound was obtained as a yellow solid.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07834019B2
Quelldatensatzuspto-grants-2010_11
ORD IDord-3a6ce5ec99624181b11a0773d017189c
Quellennotizuspto-grants-2010_11