Chlorosuccinimide → 5-[(6,7-Dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzonitrile

HRID 1172794Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1172794
FC(F)(F)C([O-])=O.[Cl:8][C:9]1[CH:10]=[C:11]2[C:16](=[O:17])[NH:15][CH:14]=[C:13]([CH2:18][C:19]3[CH:20]=[CH:21][C:22]([F:34])=[C:23]([CH:33]=3)[C:24]([N:26]3CCC[NH2+]CC3)=O)[N:12]2[CH:35]=1.[Cl:36]C1C=C2C(=O)NC=C(CC3C=CC(F)=C(C=3)C#N)N2C=1.ClN1C(=O)CCC1=O>C1COCC1>[Cl:36][C:35]1[N:12]2[C:13]([CH2:18][C:19]3[CH:20]=[CH:21][C:22]([F:34])=[C:23]([CH:33]=3)[C:24]#[N:26])=[CH:14][NH:15][C:16](=[O:17])[C:11]2=[CH:10][C:9]=1[Cl:8]

Komponenten

5

Edukt 3

HCID 31398ChlorosuccinimideHCID 686864115-[(7-Chloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzonitrileHCID 686892094-{5-[(7-Chloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoyl}-1,4-diazepan-1-ium trifluoroacetate

Produkt 1

HCID 252240505-[(6,7-Dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of Example 6, F5 (1 eq) and N-chlorosuccinimide (2 eq) in THF was stirred at RT. The solvent was removed under reduced pressure and the resulting crude was used as such in the next step without purification. MS (ES) C15H8Cl2FN3O requires: 335, found: 336 (M+H)+.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customwithout purification

Quellen und Nachweise

ORD-Eintrag
ord-d2f68aff7fb94656ae179ce69d097b17
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834015B2

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