Ammonia → 1H-pyrrolo[2,3-c]pyridin-7-amine

HRID 1173108

Reaktionsgleichung

Reaktionsgleichung von HRID 1173108
N.Br[C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][NH:9][C:8]=12.BrC1C([N+]([O-])=O)=CC=C[N:14]=1>[Cu]>[NH2:14][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[CH:11]=[CH:10][NH:9][C:8]=12

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 5550542-Bromo-3-nitropyridineHCID 196964567-Bromo-6-azaindole

Produkt 1

HCID 190801861H-pyrrolo[2,3-c]pyridin-7-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23978CopperKatalysator

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To 84 ml of aqueous concentrated ammonia were added 600 mg (3.05 mmol) of 7-bromo-1H-pyrrolo[2,3-c]pyridine synthesized from 2-bromo-3-nitropyridine in the same manner as in Production Example 1a, 194 mg of a copper powder and 603 mg of cuprous chloride. The mixture was heated in a sealed tube at 120° C. for 15 hours and then treated, to give 170 mg of 7-amino-1H-pyrrolo[2,3-c]pyridine. The resulting product was reacted and treated in the same manner as in Examples 1a and 2a, to give 57 mg of the title compound.

Aufarbeitung

  1. additiontreated

Quellen und Nachweise

ORD-Eintrag
ord-1984b068d707462f827e7c0a08a19cc2
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834049B2

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