Potassium Carbonate → 6-Ethoxycarbonylamino-1-methyl-3,4-dihydroisoquinoline

HRID 1173128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1173128
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:8]=1)(=O)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>>[CH2:17]([O:16][C:14]([NH:13][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[C:1]([CH3:2])=[N:4][CH2:5][CH2:6]2)=[O:15])[CH3:18]

Komponenten

3

Edukt 2

HCID 11430Potassium CarbonateHCID 22674171N-Acetyl-N-(3-ethoxycarbonylaminophenethyl)amine

Produkt 1

HCID 226741196-Ethoxycarbonylamino-1-methyl-3,4-dihydroisoquinoline

Versuchsvorschrift

Using N-acetyl-N-(3-ethoxycarbonylaminophenethyl)amine (1.0 g, Production Example 30b), a cyclization reaction was run according to the method described in Heterocycles 31 (2), 341 (1990). After the reaction was completed, the reaction solution was poured into ice and basified with potassium carbonate. Then, the solution was extracted with ethyl acetate, and the extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound as a brown oil.

Aufarbeitung

  1. customa cyclization reaction
  2. additionthe reaction solution was poured into ice
  3. extractionThen, the solution was extracted with ethyl acetate
  4. washthe extract was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d9621e8322f34164b9aff0b78474d536
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834049B2

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