Sodium Hydroxide → 1-Methylisoquinolin-6-amine

HRID 1173130Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1173130
C(OC([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([CH3:17])=[N:12][CH:11]=[CH:10]2)=O)C.[OH-].[Na+].[Cl-].[NH4+]>C(O)C>[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([CH3:17])=[N:12][CH:11]=[CH:10]2

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 226741466-Ethoxycarbonylamino-1-methylisoquinoline

Produkt 1

HCID 226740791-Methylisoquinolin-6-amineAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

6-Ethoxycarbonylamino-1-methylisoquinoline (0.629 g, Production Example 32b) was dissolved in ethanol (20 ml), to which was then added an aqueous 8 N sodium hydroxide solution (6.8 ml), followed by heating under reflux for 1.5 hours. After cooling as it was to room temperature, an aqueous saturated ammonium chloride was added thereto and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound (0.311 g, 72%) as pale yellow crystals.

Aufarbeitung

  1. temperatureby heating
  2. temperatureunder reflux for 1.5 hours
  3. temperatureAfter cooling as it
  4. customwas to room temperature
  5. extractionthe mixture was extracted with ethyl acetate
  6. washThe extract was washed with brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-182de88d0e7c4a4a9416dc21e1e9f246
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834049B2

Notizen zur Reaktion

Wird geladen…