Ethanol → HCID 11819299, Verbindung

HRID 1173765Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1173765
Cl[CH:2]([CH:8]([OH:12])[CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(O)C.[O-]CC.[Na+].C(O)C>CCCCCC>[CH2:9]([C@@H:8]1[O:12][C@H:2]1[C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:10][CH3:11]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 22298443HCID 22298443, VerbindungHCID 23706232Ethanol sodium ethoxide

Produkt 1

HCID 11819299HCID 11819299, VerbindungAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8058HexaneLösungsmittel

Versuchsvorschrift

Ethyl 2-chloro-3-hydroxyhexanoate synthesized in Example 9 (0.8 g, 4 mmol), ethanol (3 ml) and 20% sodium ethoxide/ethanol solution (1.52 g, 1.1 equivalents) were mixed, and the mixture was stirred at room temperature for 30 minutes. Hexane (10 ml) was added, and the mixture was washed with water (10 ml×twice). After the mixture was dried with anhydrous magnesium sulfate, the inorganic salt was separated by filtration. The filtrate was concentrated under reduced pressure. The title compound was obtained as a colorless oil (0.9 g, yield: 87%, (2R,3S) was the main ingredient).

Aufarbeitung

  1. washthe mixture was washed with water (10 ml×twice)
  2. dry with materialAfter the mixture was dried with anhydrous magnesium sulfate
  3. customthe inorganic salt was separated by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6471f42b52b3415e8e1c15bc4123de96
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07834190B2

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