Hydrochloric Acid → 4-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}naphthalene-1-carboxylic Acid

HRID 1173881Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1173881
C[O:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([CH2:15][N:16]([CH2:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)[CH2:17][C:18]2[NH:19][CH:20]=[CH:21][N:22]=2)=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].Cl>CO>[NH:19]1[CH:20]=[CH:21][N:22]=[C:18]1[CH2:17][N:16]([CH2:15][C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=1)[CH2:23][C:24]1[NH:28][CH:27]=[CH:26][N:25]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 669413384-{[bis(1H-imidazol-2-ylmethyl)amino]methyl)naphthalene-1-carboxylic acid methyl ester

Produkt 1

HCID 210844614-{[bis(1H-imidazol-2-ylmethyl)amino]methyl}naphthalene-1-carboxylic AcidAusbeute 104,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The compound (675 mg) obtained in Example 36-3 was added with methanol (7.0 ml) and a 1 mol/l sodium hydroxide (7.0 ml), followed by stirring for 1 hour. After completion of the reaction, 1 mol/l hydrochloric acid (8.0 ml) was added to adjust the solution to pH 4. Then, the solvent was distilled off and the residue was washed with methanol, followed by drying. Consequently, the subject compound (677 mg) was obtained as a white solid.

Aufarbeitung

  1. additionwas added
  2. distillationThen, the solvent was distilled off
  3. washthe residue was washed with methanol
  4. customby drying

Quellen und Nachweise

ORD-Eintrag
ord-52fc4b43bc914f079566b45c9e703e50
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07833991B2

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