tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate → (S)-3,3-Dimethyl-2-(methylsulfonamido)butanoic acid

Reaktionsgleichung

[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([O:11]C(C)(C)C)=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]>Cl.O1CCOCC1>[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([OH:11])=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]

Komponenten

Versuchsvorschrift

A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).

Aufarbeitung

customthe solvents were evaporated

Quellen und Nachweise

ORD-Eintrag: ord-b2894561c7914198ba750d8652d40cbb
Quelldatensatz: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07834043B2

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Komponenten

Edukt 1

HCID 86599586tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate

Produkt 1

HCID 61142133(S)-3,3-Dimethyl-2-(methylsulfonamido)butanoic acidAusbeute 106,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittel

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).

Aufarbeitung

customthe solvents were evaporated

Quellen und Nachweise

ORD-Eintrag: ord-b2894561c7914198ba750d8652d40cbb
Quelldatensatz: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07834043B2

Notizen zur Reaktion

Wird geladen…