HCID 59558452, Verbindung → 4-azaspiro[2.5]octane-5,7-dione
Reaktionsgleichung
COC([CH:5]1[C:12](=[O:13])[CH2:11][C:8]2([CH2:10][CH2:9]2)[NH:7][C:6]1=[O:14])=O>C(#N)C.O>[CH2:9]1[C:8]2([CH2:11][C:12](=[O:13])[CH2:5][C:6](=[O:14])[NH:7]2)[CH2:10]1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
5,7-Dioxo-4-aza-spiro[2.5]octane-6-carboxylic acid methyl ester (162 mg; 0.852 mmol) is refluxed in acetonitrile/water (3 ml; 9:1) for 1 hour. The reaction mixture is evaporated to dryness and taken up in EtOAc/MeOH, filtered from undissolved material and evaporated to yield the title compound as light-brown solid (102 mg; 85%). 1H-NMR (400 MHz; DMSO-d6): 8.28 (s, 1H); 3.59 (s, 2H); 2.48 (s, 2H); 0.83 (m. 2H); 0.70 (m, 2H). MS (m/z) ES+: 140 (MH+).
Aufarbeitung
- customThe reaction mixture is evaporated to dryness
- filtrationfiltered from undissolved material
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-c477827b87aa4be6a9e9f256d51b4558
- Quelldatensatz
- uspto-grants-2010_11
- Patentnummer
- US07838674B2
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