Sulfamide → 4-Ethanesulfonylpiperazine-1-sulfonamide

HRID 1175449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1175449
[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].[S:12](N)([NH2:15])(=[O:14])=[O:13]>O1CCOCC1>[CH2:1]([S:3]([N:6]1[CH2:7][CH2:8][N:9]([S:12]([NH2:15])(=[O:14])=[O:13])[CH2:10][CH2:11]1)(=[O:5])=[O:4])[CH3:2]

Komponenten

4

Edukt 2

HCID 82267SulfamideHCID 4152941-(Ethanesulfonyl)piperazine

Produkt 1

HCID 536283734-Ethanesulfonylpiperazine-1-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of 1-ethanesulfonylpiperazine (1.0 g) in dioxane (10 ml) was added sulfamide (0.51 g). The reaction was then heated at 100° C. for 24 h. The reaction was allowed to cool before being concentrated in vacuo. The residue was stirred in Et2O for 4 h and the mixture filtered to give the product as a white solid. Yield: 1.3 g.

Aufarbeitung

  1. temperatureto cool
  2. concentrationbefore being concentrated in vacuo
  3. filtrationthe mixture filtered

Quellen und Nachweise

ORD-Eintrag
ord-1a2b9eeb94a54934a6adebcb257ee786
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07838675B2

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