HCID 86619885, Verbindung → 1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

HRID 1175473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1175473
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

Komponenten

3

Edukt 1

HCID 86619885HCID 86619885, Verbindung2×

Produkt 1

HCID 52261,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

Aufarbeitung

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

Quellen und Nachweise

ORD-Eintrag
ord-0520002448ed40f19db55497713bce3f
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07838675B2

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