4-Methyl-3-thiopheneboronic acid → Ethyl 2-(3-methoxy-4-(4-methylthiophen-3-yl)phenyl)acetate

HRID 1175612Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1175612
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:6]=[CH:7][C:8]=1OS(C(F)(F)F)(=O)=O.[CH3:23][C:24]1[C:25](B(O)O)=[CH:26][S:27][CH:28]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:6]=[CH:7][C:8]=1[C:25]1[C:24]([CH3:23])=[CH:28][S:27][CH:26]=1

Komponenten

3

Edukt 2

HCID 50839314-Methyl-3-thiopheneboronic acidHCID 58820079Ethyl (3-methoxy-4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

Produkt 1

HCID 68775428Ethyl 2-(3-methoxy-4-(4-methylthiophen-3-yl)phenyl)acetateAusbeute 72 %

Versuchsvorschrift

Prepared in a similar manner to example 1 from ethyl 2-(3-methoxy-4-(trifluoromethylsulfonyloxy)phenyl)acetate (example 27d) and 4-methylthiophen-3-ylboronic acid. Yield: 72%. 1H NMR (400 MHz, dMSO): δ 1.19-1.22 (m, 3H), 2.00 (s, 3H), 3.62 (s, 2H), 3.69-3.73 (m, 3H), 4.08-4.13 (m, 2H), 6.86-6.88 (d, 1H), 6.98-6.99 (d, 1H), 7.08-7.10 (d, 1H), 7.16-7.17 (t, 1H), 7.26-7.27 (d,1H).

Quellen und Nachweise

ORD-Eintrag
ord-ad391cb7dfed4f9ebfbd57e4f9441513
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842324B2

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