2-Bromo-1-bromomethyl-3-nitrobenzene → Benzyl 3-(2-bromo-3-nitrobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Bromo-1-bromomethyl-3-nitrobenzene	HCID 11066342	—
Edukt	Benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate	HCID 68499596	—
Produkt	Benzyl 3-(2-bromo-3-nitrobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate	HCID 68502204	—

Reaktionsschritte

Analogously to Method D, 1.30 g of benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]-phenyl}piperidine-1-carboxylate (Example 10f) and 1.0 g of 2-bromo-1-bromomethyl-3-nitrobenzene are reacted. The title compound is obtained as a yellowish oil. Rf=0.29 (1:1 EtOAc-heptane); Rt=6.12.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07842688B2
Quelldatensatz	uspto-grants-2010_11
ORD ID	ord-62597cd8fd424b31aa87ce922fb704b1
Quellennotiz	uspto-grants-2010_11