Methylamine → 4-(2-hydroxyphenyl)-N-methylbutyramide

HRID 1176398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1176398
[O:1]1[C:7](=[O:8])[CH2:6][CH2:5][CH2:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[CH3:13][NH2:14]>C(O)(C)C>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][CH2:6][C:7]([NH:14][CH3:13])=[O:8]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 109757954,5-Dihydrobenzo[b]oxepin-2(3H)-one

Produkt 1

HCID 685011294-(2-hydroxyphenyl)-N-methylbutyramide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A solution of 1.0 g of 4,5-dihydro-3H-benzo[b]oxepin-2-one and 40 ml of 10% methylamine in isopropanol is heated in an autoclave at 100° C. over 16 hours. The reaction mixture is cooled to room temperature and concentrated by evaporation. The title compound is obtained as white crystals from the residue by means of flash chromatography (SiO2 60F). Rf=0.20 (4:1 EtOAc-heptane); Rt=2.66.

Aufarbeitung

  1. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-46c0c9a46292460a8488aa84ee483bde
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842688B2

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